Active substance mg/g Moxidectin 19.5 Praziquantel 121.7 Excipients Benzyl alcohol (E1519) 220.0 Butylhydroxytoluene (E321) 0.8
In horses: EQUEST® Pramox Oral Gel is a parasiticide active against a wide range of internal and external parasites of horses, ponies, mares and foals. It contains moxidectin, a second generation macrocyclic lactone of the milbemycin family. Moxidectin paralyses and kills parasites by its effect on their nervous systems. It also contains praziquantel, a parasiticide widely used in many species for the specific control of tapeworm. Praziquantel is quickly absorbed via the tegument of the tapeworm and distributed evenly within the parasite. It disrupts the metabolism of the tapeworm, resulting in contraction and paralysis of the parasite. EQUEST® Pramox Oral Gel treats mixed cestodes and nematodes or arthropods infections caused by moxidectin and praziquantel sensitive strains of: Large redworm (large strongyles): Strongylus vulgaris (adults stages) Strongylus edentatus (adults stages) Triodontophorus brevicauda (adults) – Triodontophorus serratus (adults) – Triodontophorus tenuicollis (adults) Small redworm (Cyathostomin/small strongyles) (adults and intraluminal larval stages): – Cyathostomum spp. – Cylicocyclus spp. – Cylicostephanus spp. – Cylicodontophorus spp. – Gyalocephalus spp. Asca rids: – Parascaris equorum (adults)
Other roundworm species: – Pinworms: Oxyuris equi (adult stages) – Stomach worms: Habronema muscae (adults) Bots: Gasterophilus intestinalis (L2, L3) Bots: Gasterophilus nasalis (L2, L3) – Strongyloides westeri (adults) – Trichostrongylus axei (adult stages) Tapeworm (adults): – Anoplocephala perfoliata – Anoplocephala magna – Paranoplocephala mammillana The product is effective against benzimidazole resistant strains of cyathostomes. The egg reappearance period of small strongyles is 90 days. The product is effective against (developing) intramucosal L4 stages of small strongyles. At 8 weeks after treatment, early (hypobiotic) EL3 stages of small strongyles are eliminated. The veterinary medicinal product has been shown to be safe for use in breeding, pregnant and lactating mares. The administration of the product does not adversely affect the fertility of the mares. Dosing Guideline: The 90-day egg reappearance period of EQUEST Pramox and its effectiveness against inhibited and developing larvae in the intestinal mucosa enables a reduction in the dosing frequency in strategic parasite control programmes. The recommended dosing interval for the control of small redworm (cyathostomin/small strongyles) is 13 weeks. Veterinary advice should be given on appropriate dosing programmes and stock management to achieve optimum parasite control. In the case of cestode treatment the dose of praziquantel in the product has been selected to the top end of the dosing range.
Do not administer to young foals less than 6.5 months old. Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
The product has been formulated specifically for use in horses only. Dogs and cats may be adversely affected by the concentration of moxidectin in this product if they are allowed to ingest spilled gel or have access to used syringes.
ADVERSE REACTIONS :
Flaccid lower lip, ataxia and swelling of the muzzle could be observed on rare occasions in young animals. These adverse effects are transient and disappear spontaneously. In case of very high worm burdens, destruction of the parasites may cause a mild transient colic and loose faeces in the treated horse. Flaccid lower lip and swelling of the muzzle could be observed on very rare occasions. These adverse effects are transient and disappear spontaneously. In adults transient adverse reactions may occur at 3 times the recommended dose. The symptoms are depression, inappetence, ataxia, flaccid lower lip in the 8 to 24 hours following treatment. Symptomatic treatment is not generally necessary and recovery is generally complete within 24 to 72 hours. There is no specific antidote. If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.
DOSAGE FOR EACH SPECIES, ROUTE AND METHOD OF ADMINISTRATION:
A single oral dose of 400 1.ig moxidectin/kg bodyweight and 2.5 mg praziquantel/kg bodyweight using the calibrated syringe of one gradation per 25 kg live weight. To ensure administration of a correct dosage, body weight should be determined as accurately as possible; accuracy of the dosing should be checked. Use of a scale or weight tape is recommended to ensure accurate dosing. Hold the syringe with the capped end pointing to the left so that you can see the weight measurements and tick marks (small black lines). Each tick mark relates to 25 kg of bodyweight. Turn the dial ring until the left side of the ring lines up with the weight of the animal. A single syringe treats a 700 kg horse. In the case of cestode treatment the dose of praziquantel in the product has been selected to the top end of the dosing range. Veterinary advice should be given on appropriate dosing programmes and stock management to achieve optimum parasite control.
Meat and offal: 64 days. Milk: not permitted for use in lactating mares producing milk for human consumption.
SPECIAL STORAGE PRECAUTIONS:
Keep out of the reach and sight of children. Do not store above 25 °C. Do not use after the expiry date stated on the carton after “EXP”. Shelf-life after first opening the container: 6 months.
HDPE syringe containing 14.4 g of gel with a graduated polypropylene plunger with a LDPE cap packed as follows: – Box containing one syringe. – Box containing 10 individually boxed syringes. – Box containing 20 individually boxed syringes – Box containing 20 syringes